PrEP is 99% effective when taken daily

PrEP, or pre-exposure prophylaxis, is a once-a-day pill that can help prevent you from getting HIV if you are exposed to the virus.
• PrEP can stop HIV from taking hold and spreading throughout your body.
• If taken as prescribed, PrEP is highly effective for preventing HIV from sex or injection drug use.
• PrEP is much less effective when not taken as prescribed.

Remember, PrEP protects you against HIV but not against pregnancy or other STIs.

Coming soon - injectable PrEP!

Is PrEP Right for Me?

PrEP can be for everyone, regardless of age, gender, sexual orientation, or relationship status. If you are HIV negative and want additional protection from HIV, PrEP may be a good option for you, especially if:

  • Your partner’s HIV status is not known
  • You’ve had an STI in the past 6 months
  • You use injection drugs
  • Your partner is living with HIV

Ultimately, PrEP puts you in control of your HIV status, regardless of the HIV status or behaviors of your sexual partner(s). When taken properly, PrEP offers you nearly 99% protection against HIV.



Some people in clinical studies of PrEP experienced upset stomach, loss of appetite, or other digestive issues, but these were mild and usually went away in one month. No serious side effects were observed, but you should tell your health care provider if these or other symptoms become severe or do not go away. While on PrEP, your provider will closely monitor any changes PrEP may have on your health.


Most insurance plans, including Colorado Medicaid, cover the cost of PrEP. Co-pays and/or deductibles may still apply. However, there are payment assistance programs that you may qualify for that provides PrEP at low or no cost.

Our PrEP navigators can help you connect to all forms of health care payment options. We can help you explore your options if you are concerned about paying for PrEP.